SBML2TikZ

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The graph below shows a pathway for Calcium/Calmodulin dependent kinase activation drawn by Ralph Gauges himself. SBML2TikZ is capable of rendering anything stored in the SBML render extension, including hand-drawn diagrams like the one here. (Note: There is a known error displaying this page in FireFox; the graph simply does not show up. Internet Explorer and Google Chrome display the page correctly.)

PGF/TikZ Output
\documentclass{article}
\usepackage{tikz}
\usepackage{pgf}
\usepackage[total={1400pt,1000pt}, centering, a1paper, landscape]{geometry}
\pagestyle{empty}
\begin{document}
\begin{center}
\begin{tikzpicture}[xscale = 1, yscale = -1]
{
% List of colors used:
\definecolor{red}{RGB}{201,0,0};
\definecolor{black}{RGB}{0,0,0};
\definecolor{white}{RGB}{255,255,255};
\definecolor{gray}{RGB}{141,141,141};
\definecolor{green}{RGB}{127,211,66};
\definecolor{blue}{RGB}{25,99,200};
\definecolor{yellow}{RGB}{233,236,53};
\definecolor{lightyellow}{RGB}{233,236,136};
{
   % Group for reaction_0
   \draw[line width = 2pt, color = black!100,  ] (660pt, 460pt) -- (700pt, 460pt);
   \draw[line width = 2pt, color = black!100,  ] (740pt, 460pt) -- (770pt, 460pt);
   {
      \pgftransformshift{\pgfpoint{ 770pt }{ 460pt } }
      \pgftransformcm { 1 }{ 0 }{ 0 }{ 1 }{\pgfpoint{ 0pt }{ 0pt } }
      {
         % LineEnding for speciesReference_reaction0_species2
         {
            % Polygon for speciesReference_reaction0_species2
            \pgftransformshift{\pgfpoint{ 0pt }{ -3pt } }
            \draw [line width = 2pt, color = black!100, fill = none ]
            (0pt,0pt)--(10pt,3pt)--(10pt,3pt)--(0pt,6pt);
         }
      }
   }
   \draw[line width = 2pt, color = black!100,  ] (700pt, 460pt) -- (740pt, 460pt);
}
{
   % Group for reaction_1
   \draw[line width = 2pt, color = black!100,  ] (1210pt, 250pt) .. controls (1320pt, 460pt) and (1331pt, 441pt) .. (1211pt, 613pt);
   \draw[line width = 2pt, color = black!100,  ] (1050pt, 450pt) .. controls (1220pt, 450pt) and (1331pt, 441pt) .. (1211pt, 613pt);
   \draw[line width = 2pt, color = black!100,  ] (1202pt, 627pt) .. controls (1178pt, 661pt) and (1185pt, 649pt) .. (1170pt, 670pt);
   {
      \pgftransformshift{\pgfpoint{ 1170pt }{ 670pt } }
      \pgftransformcm { -0.5812382 }{ 0.8137335 }{ 0.8137335 }{ 0.5812382 }{\pgfpoint{ 0pt }{ 0pt } }
      {
         % LineEnding for speciesReference_reaction1_species3
         {
            % Polygon for speciesReference_reaction1_species3
            \pgftransformshift{\pgfpoint{ 0pt }{ -3pt } }
            \draw [line width = 2pt, color = black!100, fill = none ]
            (0pt,0pt)--(10pt,3pt)--(10pt,3pt)--(0pt,6pt);
         }
      }
   }
   \draw[line width = 2pt, color = black!100,  ] (1211pt, 613pt) .. controls (1199pt, 630pt) and (1214pt, 610pt) .. (1202pt, 627pt);
}
{
   % Group for reaction_2
   \draw[line width = 2pt, color = black!100,  ] (830pt, 880pt) -- (745pt, 880pt);
   \draw[line width = 2pt, color = black!100,  ] (775pt, 764pt) .. controls (775pt, 880pt) and (775pt, 880pt) .. (745pt, 880pt);
   \draw[line width = 2pt, color = black!100,  ] (705pt, 880pt) -- (595pt, 880pt);
   {
      \pgftransformshift{\pgfpoint{ 595pt }{ 880pt } }
      \pgftransformcm { -1 }{ 0 }{ 0 }{ 1 }{\pgfpoint{ 0pt }{ 0pt } }
      {
         % LineEnding for speciesReference_reaction2_species6
         {
            % Polygon for speciesReference_reaction2_species6
            \pgftransformshift{\pgfpoint{ 0pt }{ -3pt } }
            \draw [line width = 2pt, color = black!100, fill = none ]
            (0pt,0pt)--(10pt,3pt)--(10pt,3pt)--(0pt,6pt);
         }
      }
   }
   \draw[line width = 2pt, color = black!100,  ] (705pt, 880pt) .. controls (675pt, 880pt) and (675pt, 880pt) .. (675pt, 794pt);
   {
      \pgftransformshift{\pgfpoint{ 675pt }{ 794pt } }
      \pgftransformcm { 0 }{ -1 }{ -1 }{ 0 }{\pgfpoint{ 0pt }{ 0pt } }
      {
         % LineEnding for speciesReference_reaction2_species7
         {
            % Polygon for speciesReference_reaction2_species7
            \pgftransformshift{\pgfpoint{ 0pt }{ -3pt } }
            \draw [line width = 2pt, color = black!100, fill = none ]
            (0pt,0pt)--(10pt,3pt)--(10pt,3pt)--(0pt,6pt);
         }
      }
   }
   \draw[line width = 2pt, color = black!100,  ] (745pt, 880pt) -- (705pt, 880pt);
}
{
   % Group for reaction_3
   \draw[line width = 2pt, color = black!100,  ] (230pt, 760pt) .. controls (185pt, 703pt) and (205pt, 729pt) .. (181pt, 697pt);
   \draw[line width = 2pt, color = black!100,  ] (154pt, 660pt) .. controls (124pt, 619pt) and (150pt, 605pt) .. (210pt, 605pt);
   {
      \pgftransformshift{\pgfpoint{ 210pt }{ 605pt } }
      \pgftransformcm { 1 }{ 0 }{ 0 }{ 1 }{\pgfpoint{ 0pt }{ 0pt } }
      {
         % LineEnding for speciesReference_reaction3_species0
         {
            % Polygon for speciesReference_reaction3_species0
            \pgftransformshift{\pgfpoint{ 0pt }{ -3pt } }
            \draw [line width = 2pt, color = black!100, fill = none ]
            (0pt,0pt)--(10pt,3pt)--(10pt,3pt)--(0pt,6pt);
         }
      }
   }
   \draw[line width = 2pt, color = black!100,  ] (154pt, 660pt) .. controls (34pt, 495pt) and (50pt, 530pt) .. (180pt, 300pt);
   {
      \pgftransformshift{\pgfpoint{ 180pt }{ 300pt } }
      \pgftransformcm { 0.4920573 }{ -0.8705629 }{ 0.8705629 }{ 0.4920572 }{\pgfpoint{ 0pt }{ 0pt } }
      {
         % LineEnding for speciesReference_reaction3_species8
         {
            % Polygon for speciesReference_reaction3_species8
            \pgftransformshift{\pgfpoint{ 0pt }{ -3pt } }
            \draw [line width = 2pt, color = black!100, fill = none ]
            (0pt,0pt)--(10pt,3pt)--(10pt,3pt)--(0pt,6pt);
         }
      }
   }
   \draw[line width = 2pt, color = black!100,  ] (154pt, 660pt) .. controls (34pt, 495pt) and (250pt, 470pt) .. (310pt, 470pt);
   {
      \pgftransformshift{\pgfpoint{ 310pt }{ 470pt } }
      \pgftransformcm { 1 }{ 0 }{ 0 }{ 1 }{\pgfpoint{ 0pt }{ 0pt } }
      {
         % LineEnding for speciesReference_reaction3_species1
         {
            % Polygon for speciesReference_reaction3_species1
            \pgftransformshift{\pgfpoint{ 0pt }{ -3pt } }
            \draw [line width = 2pt, color = black!100, fill = none ]
            (0pt,0pt)--(10pt,3pt)--(10pt,3pt)--(0pt,6pt);
         }
      }
   }
   \draw[line width = 2pt, color = black!100,  ] (181pt, 697pt) .. controls (157pt, 666pt) and (169pt, 680pt) .. (154pt, 660pt);
}
{
   % Group for reaction_4
   \draw[line width = 2pt, color = black!100,  ] (595pt, 155pt) -- (650pt, 155pt);
   \draw[line width = 2pt, color = black!100,  ] (690pt, 155pt) .. controls (765pt, 155pt) and (765pt, 155pt) .. (765pt, 84pt);
   {
      \pgftransformshift{\pgfpoint{ 765pt }{ 84pt } }
      \pgftransformcm { 0 }{ -1 }{ -1 }{ 0 }{\pgfpoint{ 0pt }{ 0pt } }
      {
         % LineEnding for speciesReference_reaction4_species9
         {
            % Polygon for speciesReference_reaction4_species9
            \pgftransformshift{\pgfpoint{ 0pt }{ -3pt } }
            \draw [line width = 2pt, color = black!100, fill = none ]
            (0pt,0pt)--(10pt,3pt)--(10pt,3pt)--(0pt,6pt);
         }
      }
   }
   \draw[line width = 2pt, color = black!100,  ] (690pt, 155pt) -- (800pt, 155pt);
   {
      \pgftransformshift{\pgfpoint{ 800pt }{ 155pt } }
      \pgftransformcm { 1 }{ 0 }{ 0 }{ 1 }{\pgfpoint{ 0pt }{ 0pt } }
      {
         % LineEnding for speciesReference_reaction4_species4
         {
            % Polygon for speciesReference_reaction4_species4
            \pgftransformshift{\pgfpoint{ 0pt }{ -3pt } }
            \draw [line width = 2pt, color = black!100, fill = none ]
            (0pt,0pt)--(10pt,3pt)--(10pt,3pt)--(0pt,6pt);
         }
      }
   }
   \draw[line width = 2pt, color = black!100,  ] (650pt, 155pt) -- (690pt, 155pt);
}
{
   % Curve for species_4
   \pgftransformshift{\pgfpoint{ 850pt }{ 20pt } }
   \pgftransformcm { 1 }{ 0 }{ 0 }{ 1 }{\pgfpoint{ 0pt }{ 30pt } }
   \draw [line width = 1pt, black!100, fill = gray!100 ]
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{
   % Curve for species_4
   \pgftransformshift{\pgfpoint{ 850pt }{ 20pt } }
   \draw [line width = 1pt, color = black!100 ]
   (175pt,55pt)--(220pt,20pt);
}
{
   % Curve for species_4
   \pgftransformshift{\pgfpoint{ 850pt }{ 20pt } }
   \draw [line width = 1pt, color = black!100 ]
   (170pt,210pt)--(165pt,225pt);
}
{
   % Text for species_4
   \draw (1319.681pt, 118.1458pt) node[text = black!100, font = \fontsize{ 16 } { 16 }\fontfamily{ptm}\selectfont] { COOH };
}
{
   % Text for species_4
   \draw (1104.42pt, 208.1458pt) node[text = black!100, font = \fontsize{ 16 } { 16 }\fontfamily{ptm}\selectfont] { NH };
}
{
   % Text for species_4
   \draw (1115.656pt, 205.2161pt) node[text = black!100, font = \fontsize{ 10 } { 10 }\fontfamily{ptm}\selectfont] { 2 };
}
{
   % Text for species_4
   \draw (1122.273pt, 46.5026pt) node[text = black!100, font = \fontsize{ 14 } { 14 }\fontfamily{ptm}\selectfont] { inhibitory domain };
}
{
   % Text for species_4
   \draw (1025.664pt, 271.5026pt) node[text = black!100, font = \fontsize{ 14 } { 14 }\fontfamily{ptm}\selectfont] { catalytic };
}
{
   % Text for species_4
   \draw (1021.95pt, 286.5026pt) node[text = black!100, font = \fontsize{ 14 } { 14 }\fontfamily{ptm}\selectfont] { domain };
}
{
   % Curve for species_1
   \pgftransformshift{\pgfpoint{ 350pt }{ 400pt } }
   \pgftransformcm { 1 }{ 0 }{ 0 }{ 1 }{\pgfpoint{ 170pt }{ 0pt } }
   \draw [line width = 1pt, black!100, fill = green!100 ]
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}
{
   % Curve for species_1
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   \pgftransformcm { 1 }{ 0 }{ 0 }{ 1 }{\pgfpoint{ 0pt }{ 26pt } }
   \draw [line width = 1pt, black!100, fill = blue!100 ]
   (120.86704pt,16.645159pt)--(120.86705pt,23.536989pt)--(117.26501pt,31.290299pt)--(109.16044pt,34.736229pt)--(97.45383pt,34.736229pt)--(92.95131pt,33.874739pt)--(83.04571pt,33.874739pt)--(74.04064pt,34.736229pt)--(74.04064pt,38.182139pt)--(74.04064pt,42.489539pt)--(78.54317pt,45.073969pt)--(78.54317pt,45.073969pt)--(83.04571pt,46.796939pt)--(90.24978pt,51.104329pt)--(91.15028pt,55.411719pt)--(90.24978pt,65.749479pt)--(82.14521pt,69.195389pt)--(73.14013pt,71.779829pt)--(52.42844pt,72.641319pt)--(31.71676pt,71.779829pt)--(19.10964pt,69.195389pt)--(7.40304pt,62.303559pt)--(3.80102pt,49.381369pt)--(2pt,36.459189pt)--(6.50254pt,22.675509pt)--(9.20406pt,13.19924pt)--(18.20915pt,8.03037pt)--(29.01524pt,5.44593pt)--(44.32386pt,2.8615pt)--(61.43351pt,2pt)--(77.64267pt,2.86149pt)--(91.15029pt,7.16888pt)--(105.55841pt,10.6148pt)--(120.86704pt, 16.645159pt) -- cycle;
}
{
   % Rectangle for species_1
   \pgftransformshift{\pgfpoint{ 350pt }{ 400pt } }
   \def \wholeShape {(120pt,45pt) rectangle(177pt,55pt)}
   \fill[fill = gray!100] \wholeShape;
   \draw[line width = 1pt, color = black!100 ] \wholeShape;
}
{
   % Curve for species_8
   \pgftransformshift{\pgfpoint{ 150pt }{ 100pt } }
   \draw [line width = 1pt, black!100, fill = gray!100 ]
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}
{
   % Curve for species_8
   \pgftransformshift{\pgfpoint{ 150pt }{ 100pt } }
   \pgftransformcm { 1 }{ 0 }{ 0 }{ 1 }{\pgfpoint{ 140pt }{ 75pt } }
   \draw [line width = 1pt, color = black!100 ]
   (2pt, 2pt) .. controls (2.53572pt, 11.55357pt) and (2.53572pt, 11.55357pt) ..(2.53572pt,11.55357pt);
}
{
   % Curve for species_8
   \pgftransformshift{\pgfpoint{ 150pt }{ 100pt } }
   \pgftransformcm { 1 }{ 0 }{ 0 }{ 1 }{\pgfpoint{ 235pt }{ 120pt } }
   \draw [line width = 1pt, black!100, fill = red!100 ]
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}
{
   % Ellipses for species_8
   \pgftransformshift{\pgfpoint{ 150pt }{ 100pt } }
   \def \wholeShape {(143pt,98pt) ellipse(12pt and 12pt)}
   \fill[color = yellow!100] \wholeShape;
   \draw[line width = 1pt, color = black!100 ] \wholeShape;
}
{
   % Text for species_8
   \draw (297.6649pt, 218.1458pt) node[text = black!100, font = \fontsize{ 16 } { 16 }\fontfamily{ptm}\selectfont] { P };
}
{
   % Curve for species_2
   \pgftransformshift{\pgfpoint{ 800pt }{ 400pt } }
   \draw [line width = 1pt, black!100, fill = blue!100 ]
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}
{
   % Curve for species_2
   \pgftransformshift{\pgfpoint{ 800pt }{ 400pt } }
   \pgftransformcm { 1 }{ 0 }{ 0 }{ 1 }{\pgfpoint{ 120pt }{ 0pt } }
   \draw [line width = 1pt, black!100, fill = green!100 ]
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}
{
   % Curve for species_2
   \pgftransformshift{\pgfpoint{ 800pt }{ 400pt } }
   \pgftransformcm { 1 }{ 0 }{ 0 }{ 1 }{\pgfpoint{ 85pt }{ 68pt } }
   \draw [line width = 1pt, black!100, fill = gray!100 ]
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}
{
   % Ellipses for species_2
   \pgftransformshift{\pgfpoint{ 800pt }{ 400pt } }
   \def \wholeShape {(25pt,20pt) ellipse(5pt and 5pt)}
   \fill[color = yellow!100] \wholeShape;
   \draw[line width = 1pt, color = black!100 ] \wholeShape;
}
{
   % Ellipses for species_2
   \pgftransformshift{\pgfpoint{ 800pt }{ 400pt } }
   \def \wholeShape {(15pt,33pt) ellipse(5pt and 5pt)}
   \fill[color = yellow!100] \wholeShape;
   \draw[line width = 1pt, color = black!100 ] \wholeShape;
}
{
   % Ellipses for species_2
   \pgftransformshift{\pgfpoint{ 800pt }{ 400pt } }
   \def \wholeShape {(195pt,20pt) ellipse(5pt and 5pt)}
   \fill[color = yellow!100] \wholeShape;
   \draw[line width = 1pt, color = black!100 ] \wholeShape;
}
{
   % Ellipses for species_2
   \pgftransformshift{\pgfpoint{ 800pt }{ 400pt } }
   \def \wholeShape {(205pt,33pt) ellipse(5pt and 5pt)}
   \fill[color = yellow!100] \wholeShape;
   \draw[line width = 1pt, color = black!100 ] \wholeShape;
}
{
   % Curve for species_3
   \pgftransformshift{\pgfpoint{ 850pt }{ 700pt } }
   \pgftransformcm { 0.86603 }{ -0.5 }{ 0.5 }{ 0.86603 }{\pgfpoint{ 250pt }{ 45pt } }
   \draw [line width = 1pt, black!100, fill = green!100 ]
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}
{
   % Curve for species_3
   \pgftransformshift{\pgfpoint{ 850pt }{ 700pt } }
   \pgftransformcm { 1 }{ 0 }{ 0 }{ 1 }{\pgfpoint{ 0pt }{ 25pt } }
   \draw [line width = 1pt, black!100, fill = gray!100 ]
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}
{
   % Curve for species_3
   \pgftransformshift{\pgfpoint{ 850pt }{ 700pt } }
   \pgftransformcm { 1 }{ 0 }{ 0 }{ 1 }{\pgfpoint{ 78pt }{ 97pt } }
   \draw [line width = 1pt, black!100, fill = red!100 ]
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}
{
   % Curve for species_3
   \pgftransformshift{\pgfpoint{ 850pt }{ 700pt } }
   \pgftransformcm { 0.86602 }{ 0.5 }{ -0.5 }{ 0.86602 }{\pgfpoint{ 205pt }{ -15pt } }
   \draw [line width = 1pt, black!100, fill = blue!100 ]
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}
{
   % Curve for species_3
   \pgftransformshift{\pgfpoint{ 850pt }{ 700pt } }
   \pgftransformcm { 1 }{ 0 }{ 0 }{ 1 }{\pgfpoint{ 255pt }{ 101pt } }
   \draw [line width = 1pt, black!100, fill = gray!100 ]
   (4.92599pt, 6.19577pt) .. controls (2pt, 5.80333pt) and (18.41964pt, 23.40875pt) .. (29.21017pt, 23.36092pt) .. controls (39.92097pt, 23.31345pt) and (45.43494pt, 7.38124pt) .. (45.43494pt,7.38124pt)--(37.93282pt, 7.56084pt) .. controls (37.93282pt, 7.56084pt) and (31.24491pt, 21.93658pt) .. (23.14953pt, 15.0137pt) .. controls (7.93174pt, 2pt) and (13.7407pt, 7.32707pt) .. (13.7407pt,7.32707pt)--(4.92599pt, 6.19577pt) -- cycle;
}
{
   % Ellipses for species_3
   \pgftransformshift{\pgfpoint{ 850pt }{ 700pt } }
   \def \wholeShape {(198pt,25pt) ellipse(5pt and 5pt)}
   \fill[color = yellow!100] \wholeShape;
   \draw[line width = 1pt, color = black!100 ] \wholeShape;
}
{
   % Ellipses for species_3
   \pgftransformshift{\pgfpoint{ 850pt }{ 700pt } }
   \def \wholeShape {(210pt,15pt) ellipse(5pt and 5pt)}
   \fill[color = yellow!100] \wholeShape;
   \draw[line width = 1pt, color = black!100 ] \wholeShape;
}
{
   % Ellipses for species_3
   \pgftransformshift{\pgfpoint{ 850pt }{ 700pt } }
   \def \wholeShape {(330pt,47pt) ellipse(5pt and 5pt)}
   \fill[color = yellow!100] \wholeShape;
   \draw[line width = 1pt, color = black!100 ] \wholeShape;
}
{
   % Ellipses for species_3
   \pgftransformshift{\pgfpoint{ 850pt }{ 700pt } }
   \def \wholeShape {(350pt,50pt) ellipse(5pt and 5pt)}
   \fill[color = yellow!100] \wholeShape;
   \draw[line width = 1pt, color = black!100 ] \wholeShape;
}
{
   % Curve for species_6
   \pgftransformshift{\pgfpoint{ 150pt }{ 700pt } }
   \pgftransformcm { 0.86602 }{ -0.5 }{ 0.5 }{ 0.86602 }{\pgfpoint{ 250pt }{ 45pt } }
   \draw [line width = 1pt, black!100, fill = green!100 ]
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}
{
   % Curve for species_6
   \pgftransformshift{\pgfpoint{ 150pt }{ 700pt } }
   \pgftransformcm { 1 }{ 0 }{ 0 }{ 1 }{\pgfpoint{ 0pt }{ 25pt } }
   \draw [line width = 1pt, black!100, fill = gray!100 ]
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}
{
   % Curve for species_6
   \pgftransformshift{\pgfpoint{ 150pt }{ 700pt } }
   \pgftransformcm { 1 }{ 0 }{ 0 }{ 1 }{\pgfpoint{ 213pt }{ 175pt } }
   \draw [line width = 1pt, black!100, fill = red!100 ]
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}
{
   % Curve for species_6
   \pgftransformshift{\pgfpoint{ 150pt }{ 700pt } }
   \pgftransformcm { 0.86602 }{ 0.5 }{ -0.5 }{ 0.86602 }{\pgfpoint{ 205pt }{ -15pt } }
   \draw [line width = 1pt, black!100, fill = blue!100 ]
   (118.78248pt, 60.56123pt) .. controls (115.04965pt, 49.21963pt) and (109.29256pt, 40.00852pt) .. (109.29256pt,40.00852pt)--(97.06626pt,26.98336pt)--(75.58871pt,11.41234pt)--(59.31393pt,2.64817pt)--(38.48199pt,2pt)--(22.09503pt,7.29641pt)--(9.59874pt,16.13312pt)--(3.72948pt,20.9826pt)--(2pt,34.08966pt)--(4.05945pt,51.50804pt)--(3.7999pt,60.08033pt)--(7.38535pt, 65.93364pt) .. controls (7.38535pt, 65.93364pt) and (9.00267pt, 66.88716pt) .. (12.44074pt, 67.25219pt) .. controls (15.87882pt, 67.61722pt) and (28.31903pt, 65.8108pt) .. (28.31903pt,65.8108pt)--(39.69625pt,65.45514pt)--(45.30595pt,69.17796pt)--(54.252pt,74.03679pt)--(65.93442pt,71.36813pt)--(73.56836pt,72.96044pt)--(78.52201pt,75.04999pt)--(89.08536pt,80.86236pt)--(101.01689pt,82.91096pt)--(108.50346pt,79.015pt)--(116.19348pt,73.57702pt)--(119.99285pt,64.59875pt)--(118.78248pt, 60.56123pt) -- cycle;
}
{
   % Curve for species_6
   \pgftransformshift{\pgfpoint{ 150pt }{ 700pt } }
   \pgftransformcm { 1 }{ 0 }{ 0 }{ 1 }{\pgfpoint{ 255pt }{ 101pt } }
   \draw [line width = 1pt, black!100, fill = gray!100 ]
   (4.92599pt, 6.19577pt) .. controls (2pt, 5.80333pt) and (18.41964pt, 23.40875pt) .. (29.21017pt, 23.36092pt) .. controls (39.92097pt, 23.31345pt) and (45.43494pt, 7.38124pt) .. (45.43494pt,7.38124pt)--(37.93282pt, 7.56084pt) .. controls (37.93282pt, 7.56084pt) and (31.24491pt, 21.93658pt) .. (23.14953pt, 15.0137pt) .. controls (7.93174pt, 2pt) and (13.7407pt, 7.32707pt) .. (13.7407pt,7.32707pt)--(4.92599pt, 6.19577pt) -- cycle;
}
{
   % Curve for species_6
   \pgftransformshift{\pgfpoint{ 150pt }{ 700pt } }
   \pgftransformcm { 1 }{ 0 }{ 0 }{ 1 }{\pgfpoint{ 140pt }{ 100pt } }
   \draw [line width = 1pt, color = black!100 ]
   (2pt, 2pt) .. controls (2.53572pt, 11.55357pt) and (2.53572pt, 11.55357pt) ..(2.53572pt,11.55357pt);
}
{
   % Ellipses for species_6
   \pgftransformshift{\pgfpoint{ 150pt }{ 700pt } }
   \def \wholeShape {(143pt,123pt) ellipse(12pt and 12pt)}
   \fill[color = yellow!100] \wholeShape;
   \draw[line width = 1pt, color = black!100 ] \wholeShape;
}
{
   % Ellipses for species_6
   \pgftransformshift{\pgfpoint{ 150pt }{ 700pt } }
   \def \wholeShape {(198pt,25pt) ellipse(5pt and 5pt)}
   \fill[color = yellow!100] \wholeShape;
   \draw[line width = 1pt, color = black!100 ] \wholeShape;
}
{
   % Ellipses for species_6
   \pgftransformshift{\pgfpoint{ 150pt }{ 700pt } }
   \def \wholeShape {(210pt,15pt) ellipse(5pt and 5pt)}
   \fill[color = yellow!100] \wholeShape;
   \draw[line width = 1pt, color = black!100 ] \wholeShape;
}
{
   % Ellipses for species_6
   \pgftransformshift{\pgfpoint{ 150pt }{ 700pt } }
   \def \wholeShape {(330pt,47pt) ellipse(5pt and 5pt)}
   \fill[color = yellow!100] \wholeShape;
   \draw[line width = 1pt, color = black!100 ] \wholeShape;
}
{
   % Ellipses for species_6
   \pgftransformshift{\pgfpoint{ 150pt }{ 700pt } }
   \def \wholeShape {(350pt,50pt) ellipse(5pt and 5pt)}
   \fill[color = yellow!100] \wholeShape;
   \draw[line width = 1pt, color = black!100 ] \wholeShape;
}
{
   % Text for species_6
   \draw (297.6649pt, 842.1458pt) node[text = black!100, font = \fontsize{ 16 } { 16 }\fontfamily{ptm}\selectfont] { P };
}
{
   % Text for speciesGlyph_species9
   \draw (762.2441pt, 57.08203pt) node[text = black!100, font = \fontsize{ 18 } { 18 }\fontfamily\sfdefault\selectfont] { P };
}
{
   % Text for speciesGlyph_species9
   \draw (766.5456pt, 56.85468pt) node[text = black!100, font = \fontsize{ 12 } { 12 }\fontfamily\sfdefault\selectfont] { i };
}
{
   % Rectangle for speciesGlyph_species5
   \pgftransformshift{\pgfpoint{ 750pt }{ 730pt } }
   \def \wholeShape {(0pt,0pt) rectangle(55pt,24pt)}
   \fill[fill = red!100] \wholeShape;
   \draw[line width = 1pt, color = red!100 ] \wholeShape;
}
{
   % Text for speciesGlyph_species5
   \draw (786.291pt, 763.082pt) node[text = white!100, font = \fontsize{ 18 } { 18 }\fontfamily\sfdefault\selectfont] { ATP };
}
{
   % Rectangle for speciesGlyph_species7
   \pgftransformshift{\pgfpoint{ 650pt }{ 730pt } }
   \def \wholeShape {(0pt,0pt) rectangle(55pt,24pt)}
   \fill[fill = none] \wholeShape;
   \draw[line width = 1pt, color = red!100 ] \wholeShape;
}
{
   % Text for speciesGlyph_species7
   \draw (687.6621pt, 763.082pt) node[text = red!100, font = \fontsize{ 18 } { 18 }\fontfamily\sfdefault\selectfont] { ADP };
}
{
   % Text for speciesGlyph_species0_1
   \draw (739.7969pt, 499.482pt) node[text = black!100, font = \fontsize{ 18 } { 18 }\fontfamily\sfdefault\selectfont] { Ca };
}
{
   % Text for speciesGlyph_species0_1
   \draw (756.0612pt, 487.2547pt) node[text = black!100, font = \fontsize{ 12 } { 12 }\fontfamily\sfdefault\selectfont] { 2+ };
}
{
   % Text for speciesGlyph_species0_2
   \draw (269.7969pt, 629.4821pt) node[text = black!100, font = \fontsize{ 18 } { 18 }\fontfamily\sfdefault\selectfont] { Ca };
}
{
   % Text for speciesGlyph_species0_2
   \draw (286.0612pt, 617.2547pt) node[text = black!100, font = \fontsize{ 12 } { 12 }\fontfamily\sfdefault\selectfont] { 2+ };
}
{
   % Group for speciesGlyph_species8
   \draw (540pt, 225pt) node[text = black!100, font = \fontsize{ 18 } { 18 }\fontfamily\sfdefault\selectfont] { Ca2+-INDEPENDENT };
}
{
   % Group for speciesGlyph_species8
   \draw (540pt, 255pt) node[text = black!100, font = \fontsize{ 18 } { 18 }\fontfamily\sfdefault\selectfont] { (50-80\% ACTIVE) };
}
{
   % Group for reactionGlyph_reaction4
   \draw (660pt, 102pt) node[text = black!100, font = \fontsize{ 12 } { 12 }\fontfamily\sfdefault\selectfont] { protein };
}
{
   % Group for reactionGlyph_reaction4
   \draw (660pt, 126pt) node[text = black!100, font = \fontsize{ 12 } { 12 }\fontfamily\sfdefault\selectfont] { phosphatase };
}
{
   % Group for speciesGlyph_species4
   \draw (1210pt, 215pt) node[text = black!100, font = \fontsize{ 18 } { 18 }\fontfamily\sfdefault\selectfont] { INACTIVE };
}
{
   % Group for speciesGlyph_species1
   \draw (515pt, 512pt) node[text = black!100, font = \fontsize{ 12 } { 12 }\fontfamily\sfdefault\selectfont] { calmodulin };
}
{
   % Group for speciesGlyph_species2
   \draw (915pt, 512pt) node[text = black!100, font = \fontsize{ 12 } { 12 }\fontfamily\sfdefault\selectfont] { Ca2+/calmodulin };
}
{
   % Group for speciesGlyph_species6
   \draw (480pt, 865pt) node[text = black!100, font = \fontsize{ 18 } { 18 }\fontfamily\sfdefault\selectfont] { FULLY };
}
{
   % Group for speciesGlyph_species6
   \draw (480pt, 895pt) node[text = black!100, font = \fontsize{ 18 } { 18 }\fontfamily\sfdefault\selectfont] { ACTIVE };
}
{
   % Group for speciesGlyph_species3
   \draw (1100pt, 875pt) node[text = black!100, font = \fontsize{ 18 } { 18 }\fontfamily\sfdefault\selectfont] { ACTIVATED };
}
{
   % Group for reactionGlyph_reaction2
   \draw (725pt, 912pt) node[text = black!100, font = \fontsize{ 12 } { 12 }\fontfamily\sfdefault\selectfont] { auto- };
}
{
   % Group for reactionGlyph_reaction2
   \draw (725pt, 936pt) node[text = black!100, font = \fontsize{ 12 } { 12 }\fontfamily\sfdefault\selectfont] { phosphorylation };
}
{
   % Group for speciesGlyph_species0_1
   \draw (707.5pt, 475pt) node[text = black!100, font = \fontsize{ 18 } { 18 }\fontfamily\sfdefault\selectfont] { + };
}
{
   % Group for speciesGlyph_species8
}
{
   % Group for speciesGlyph_species4
}
{
   % Group for speciesGlyph_species3
}
{
   % Group for speciesGlyph_species6
}
{
   % Group for speciesGlyph_species9
}
{
   % Group for speciesGlyph_species0_1
}
{
   % Group for speciesGlyph_species5
}
{
   % Group for speciesGlyph_species7
}
{
   % Group for speciesGlyph_species0_2
}
}
\end{tikzpicture}
\end{center}
\end{document}